Knockdown of LRRK2 inhibits the progression of lung cancer by regulating TLR4/NF-κB pathways and NLRP3 inflammasome

Leucine-rich repeat kinase 2 (LRRK2) plays an important role in a variety of inflammatory diseases, as well peripheral and central immune responses. At present, there are few reports about the LRRK2 lung cancer, need to be further explored. The main purpose this study is explore mechanism cancer. results revealed that expression was increased tissues cancer patient cells. Further studies found interference with significantly induced apoptosis, promoted caspase-3, caspase-9 Bax. More importantly, si-LRRK2 inhibited VEGF P-gp, indicating inhibition cell proliferation drug resistance. What’s more, regulated TLR4/NF-κB signaling pathways NLRP3 inflammasome, involved molecular on In conclusion, suggested inhibiting progression regulate inflammasome.